How can we uproot colonial and systemic issues pertaining to pharmacy and substance use experienced by Indigenous peoples? That’s the question Larry Leung, Assistant Professor, Faculty of Pharmaceutical Sciences, and the UPROOT research team at the University of British Columbia will seek to answer. Collaborating with B.C.’s Nuxalk Health and Wellness, which is currently building a substance use disorders clinic, the goal is to develop a model for culturally safe pharmacy services for substance use in a remote Indigenous community. This innovative pharmacy practice model is based on the principle of iixsatimutilh, a Nuxalk saying that translates as, “We are medicine for each other.” Pharmacists will balance western ways of healing with Indigenous worldviews of health and wellness. Not only is this an opportunity to improve patient care and expand the pharmacy practice to include spiritual, cultural and land-based healing, but this project can also serve as a model for other Indigenous communities both provincially and nationally.