Pharmacist intervention has been shown to improve outcomes for patients with hypertension, dyslipidemia and other conditions. However, comprehensive medication assessments (CMA) that consider patients holistically may identify even more opportunities to improve outcomes in other ways, such as reducing potentially inappropriate medication use and improving quality of life.This study aims to show that CMA provided through a pharmacist clinic for patients with complex medication needs will improve medication-related burden, reduce medication complexity, and increase patient satisfaction.